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Ongoing MCTG Funded Research Studies

Title

Principal Investigator

Type of Study

Projected Enrollment

Funding

Status

High-volume Hemofiltration for critically ill burn patients with septic shock and mild acute kidney injury Kevin Chung, MD
Ft. Sam Houston, TX
Non-blinded randomized controlled trial comparing intervention with early high-volume hemofiltration (HVHF) plus 'contemporary' care alone in critically ill adult burn patients who develop septic shock with mild acute kidney injury 120 patients in 10 centers Yes

Dept of Defense Combat Casualties Grant
Pre-enrollment, accepting additional sites
Development of an inhalation injury scoring system Kevin Foster, MD
Phoenix, AZ
Non-interventional, multi-center, 2-phase prospective trial to construct and validate an accurate and predictive scoring system for burn subjects with inhalation injury 1,000 patients 15-20 centers Yes

Dept of Defense Combat Casualties Grant
Pre-enrollment, not accepting additional sites
Effects of enteral glutamine supplementation on mortality and infectious morbidity in severly burned patients Paul Wischmeyer, MD
Univ. Colorado
Prospective, double-blinded randomized clinical trial of the effect of glutamine supplementation of enteral nutrition on infectious morbidity/mortality in burn patients 1014 pts with burns ≥ 20% TBSA Yes

Dept of Defense Combat Casualties Grant
Pre-enrollment, not accepting additional sites
PCR-based detection of Staph aureus in burn patients Nam Tran, PhD
Sacramento, CA
PRCT using the only FDA-approved near-patient nucleic acid recognition (NAR) device for the detection of methicillin sensitive Staphylococcus aureus (MSSA), and methicillin resistant Staphylococcus aureus (MRSA). 240 patients in 4 centers Yes

Dept of Defense Combat Casualties Grant
Pre-enrollment, not accepting additional sites
Community-based exercise program in adults with severe burns Oscar Suman, PhD
Galveston, TX
Prospective, randomized, controlled evaluation of a structured exercise program on burn rehabilitation 60 pts over 2 years Yes

Dept of Defense Combat Casualties Grant
Pre-enrollment, not accepting additional sites

Prospective, Randomized Trial of Restrictive Versus Liberal Blood Transfusion Policy in Burns Greater than 20% TBSA

Tina Palmieri, MD
U California, Davis

Prospective, randomized, clinical trial of restrictive (Hgb 7-8 gr/dL) is associated with equivalent survival as a liberal (Hgb 9-10 gr/dL) transfusion in patients with burns ≥ 20% TBSA

400 pts ≥ 20% TBSA, 13 centers

YES USAMRMC

MCTG-sponsored

Center enrollment currently closed, patient enrollment begins summer, 2009

Burn Patient acuity Demographics, Scar contractures and Rehabilitation Treatment Time Related to Patient Outcomes

Reginald Richard, RPT USAISR

Prospective creation of descriptive patient database focusing on patient demographics, rehabilitation treatments, scar contractures, and total rehabilitation treatment time.

800 patients
19 burn centers

YES TATRC

MCTG-sponsored

Center enrollment closed, anticipate patient enrollment summer/fall 2009


Ongoing MCTG Member Initiated Research Studies

Title

Principal Investigator

Type of Study

Projected Enrollment

Funding

Status

Percutaneous Peritoneal Decompression and Abdominal Compartment Syndrome: A Prospective, Randomized, Multi-Institutional Study

Barbara Latenser, MD
University of Iowa

Prospective, randomized, unblinded study of 240 patients nationwide.  Half will receive percutaneous peritoneal decompression, controls will receive standard monitoring/ care.  

240 patients
15 centers

Catheters provided by Cook Critical Care.  PI will analyze data

Enrollment is ongoing. Five centers enrolled to date

A Comparative Study of the Recell™ Device and Autologous Split Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries

James Holmes, MD
Wake Forest University Burn Center

Prospective, randomized clinical trial of the ReCell™ epidermal suspension technique compared to conventional STSG for patients with burns ≤ 20% TBSA

100 pts ≤ 20% TBSA, 10 centers

YES AFIRM/DOD

Center enrollment closed with enrollment start date by 7/1/09

International Classification of the External Causes of Injury: ICECI

Michael Peck, MD
Arizona Burn Center

Prospective observational process evaluation of implementing software containing ICECI into existing NTRACS burn registries

10 centers (9 so far)

IAFF

Presented at 9th World Conference, Injury prevention and safety, 2008
Abstract to be presented at 2009 ABA meeting.


Completed MCTG Studies

Title

Principal Investigator

Description

Outcome

Across State Lines: Healthcare Accessibility, Fiscal and Legislative Concerns Facing the ABA Michael Peck, MD
Arizona Burn Center
Retrospective review of patients admitted to US burn centers comparing resource utilization for in-state vs. out-of-state patients Manuscript submitted for publication

Burn Mortality in Patients Age 75 Or Greater

Daniel Caruso, MD    
Karen Richey, RN    Arizona Burn Center

Review of mortality among elderly patients

Abstract presented at 2006 ABA meeting

A Retrospective Review of DRG 504

Richard Kagan, MD University of Cincinnati

Review of 107 patients with DRG 504 who required mechanical ventilation from 3 institutions documenting inadequate reimbursement for care.

Published J Burn Care Res 2007;28:664-8

Blood Transfusion in Burns: What Do We Do?

Tina Palmieri, MD
University of California Davis

Survey among 55 burn center directors documenting that "restrictive" transfusion policies are not widely followed.

Published J Burn Care Res 2004;25:71-5

Effect of Blood Transfusion on Outcome after Major Burn Injury: A Multicenter Study

Tina Palmieri, MD
University of California Davis

Review of 666 patients from 21 burn centers documenting a relationship between number of transfusions and mortality.  

Published Crit Care Med 2006;34:1602-7

Effects of Oxandrolone on Outcome Measures in the Severely Burned: A Multicenter Prospective Randomized Double-Blind Trial. Steven Wolf, MD
US Army Institute of Surgical Research

Prospective randomized trial of oxandrolone supplementation in 81 patients treated at US burn centers.

Oxandrolone patients had shorted LOS.

Published J Burn Care Res 2006;27:131-9
Current Management of Purpura Fulminans: A Multicenter Study Petra Warner, MD University of Cincinnati 10-year review of 70 patients with purpura fulminans treated at 7 burn centers. Skin grafting or amputation required in 90% of patients. Published J Burn Care Rehabil 2003;24:119-26
A Multicenter Review of Toxic Epidermal Necrolysis Treated in U.S. Burn Centers at the End of the Twentieth Century Tina Palmieri, MD University of California Davis Review of 199 patients with SJS/TENS treated at 15 burn centers from 1995-2000. Mortality of 32%. Published J Burn Care Rehabil 2002;23:87-96
Burn Depth Assessment Questionnaire Joel Fish, MD
Ross Tilley Burn Center
Abstract presented ISBI, Montreal, 2008. Manuscript submitted for publication.
The Continued "Dangerous"(?) Use of Albumin in the Management of Acute Burn Injury: A Survey of the ABA Multicenter Trials Group. Bruce Cairns, MD
NC Jaycee Burn Center
Abstract presented at 2004 ABA meeting
DRG 272: Does It Provide Adequate Burn Center Reimbursement for the Care of Patients with Toxic Epidermal Necrolysis? Richard Kagan, MD University of Cincinnati Multicenter review of 33 patients with SJS/TENS from 6 burn centers documenting inadequate reimbursement. Abstract presented at 2004 ABA Annual Meeting
Published J Burn Care Res 2007;28:669-74
A Multicenter Review of Fungal Infections In Burn Patients James Ballard, MD University of Utah Review of 435 patients with positive fungal cultures from 15 US burn centers. Systemic treatment, number of sites, and cultures positive for aspergillus or mold associated with increased mortality. Abstracts presented at 2006 and 2007 ABA Annual Meetings.

Published J Burn Care Res 2008;29:213-21

Regional Burn Center Utilization: Is the Patient Composition of Regional Burn Centers Changing?

Amalia Cochran, MD University of Utah

Retrospective review of admissions from Utah, Washington, Minnesota, Iowa, Loyola

Abstract presented at 2009 ABA Annual Meeting.

Published J Burn Care Res 2010 Jan-Feb;31(1):130-6


Proposed MCTG Studies
Title Principal Investigator Type of Study Projected Enrollment Funding Status

None at this time